L7: Overweight and obesity in old age

23 important questions on L7: Overweight and obesity in old age

Why is there little attention for obesity in older age?

There is more attention on underweight, there is more attention for prevention (so for younger people) of obesity. Because they are already old, they wouldnt benefit much from losing weight

What can be some benefits of being overweight in older age?

- higeher bone density, although conflicting evidence
- less hip fractures, because you have protection when you fall

How much % of people >65 years are overweight?

Over 60%
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What is survival bias?

Those susceptible to the effects of obesity are more likely to have died of earlier age. Thats why the prevalence of obesity decreases from age 75+ y

In which population group is obesity more present?

In older population, in women more than men

What can be the cause of the rise of obesity in older age?

Dont work anymore
less outside
less work in household
more leisure time

Name 4 reasons why there is little attention for obesity in old age

- younger populations are more economically productive
- the idea that prevention should start early in life
- limited awareness: there is a sterotype that obesity is a problem of younder age groups
- obesity is complex in old age due to comorbidity, reduced mobility, and specific nutritional needs   
- ill placed believe that obesity is normal in old age (obesity paradox)

What do observational studies say about of obesity in old age? 3 things

- more body fat leads to more mobility issues
- higher bmi: more incident pain
obesity in old age is associated with numerous health outcomes:
- diabetes
CVD
depression
pain
poor muscle strength
fractures
cancer
cognitive decline
pain
osteoarthritis
urinairy incontinence

What does RCT studies say on obesity and wieght loss in old age?

There is a 15% reduction in all-cause mortality for weight loss group

Name 5 effects of intentional weight loss by lifestyle intervention in old people studied through RCT's

- prevention DM2
reduction pain
reduction sexual disfunction
increase mobility
increase vitality
increase functional status
reduction urinairy incontinence

What is the disadvantage of the RCT's done in older adults for weight reduction?

You cannot differentiate between the effect of the weight reduction on health outcomes or the effect of physical activity, because the intervention had physical activity.

What is the evidence of the obesity paradox: bmi and mortality in old age?

Observational studies found that a normal bmi had higher mortality rates than high bmi, but there was confounding by:
- lower bmi were more sick (more recent weight loss)
- there was an association between lower bmi and smoking

What is the evidence from observational and rct studies to the obesity paradox: weight loss and mortality risk in old age?

Observational studies: found increased risk of weigth loss, but this was due to unintentional weight loss (due to disease)
RCTs: found a lower risk for mortality of intentional weight loss

How much % of overweight older people also know they are overweight?

About 85% know they are overweight. About 15% dont know

What do overweight older men and women think about their own weight? (how satisfied are they?)

Only 8% of older ovverweight men and women are satisfied with their weight.
About 60% of overweight men and women are little satisfied with their weight.

How much % of overweight older men and women are trying to lose weight or prevent weight loss?

About 20% of 70+ try to lose weight.
About 50% of 70+ try to prevent weight gain

What is the effect of lifestyle intervention on weight for older people (65+)?

After one year about 9% weight reduction is reached in this group. After 8 years still about 7% of the weight is lost.

What are the 3 ESPEN 2022 guidelines about older people and weight loss?

- in overweight older people: weight reducing diets shall be avoided to prevent loss of muscle mass
- In obese older persons with weight-related health problems, weight reducing diets shall only be considered after careful and individual weighing of benefits and risks
- If weight reduction is considered in obese older persons, energy restriction shall be only moderate in order to achieve a slow weight reduction and prevent muscle mass

What are the results on weight loss/muscle loss/ fat loss of obese older people (65+) following a very low calorie diet versus a hypocaloric diet (after 12 weeks)?
Also: what does the very low calorie diet versus a hypocaloric diet mean?

very low calorie diet: 2 - 3 meal replacements (OPTIFAST) a day
hypocaloric diet: -500 kcal/d deficit and 30% from protein
very low calorie diet lost more weight than hypocaloric diet (10 vs 5% reduction)
VLCD lost about 5% lean mass, hypocaloric about 3%.
So VLCD lost less % lean mass, but in kg, lost more lean mass.

What is the recommended amount of protein for obese older persons trying to lose weight?

Minimal 1.0 g/kg to keep muscle loss as less as possible

What is the recommendation for older obese adults trying to lose weight?

- minimal 1.0 g/kg protein
- 500 kcal reduction a day (slow weight loss)
- combine dietary interventions with physical exercise

Why should diet be combined with exercise in old obese persons for weight loss? (and not only diet or only exercise)

With only diet and diet+ exercise, you lose about the same amount of weight.
but: diet loses more muscle than diet+exercise.
with only exercise, you dont lose weight, but you do gain muscle (and lose fat)
Diet+exercise is the best combination for weight loss, muscle loss prevention, physical performance and VO2max

What is the optimal type of exercise for obese older persons and why?

Diet should be combined with resistance training to prevent accelerated loss of bone and muscle mass
to achieve optimal physical funcitoning, aerobic training should be added.

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