Summary: Reader Microbial Disease Mechanisms
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2 Structure and functio of bacterial cells
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2.2 Appendages: flagella, fimbriae and pili
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3 ways to spot bacterial movement
1. Staining technique
2. Swim medium
3. Direct observation in wet mount -
F pillus / Sex pilus
Stabilize mating during conjugation -
2.3 The cell envelope: capsules, cell walls and S-layers
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Gramnegative Cell wall
- Turns pink bystaining
- Singlepeptidoglycan layer with outer membrane
- LPS as unique component -
Penicillin & beta-lactam antibiotics action
Block transpeptidase and carboxypeptidase enzymes during the assembly of the murein cell wall -
Lipoteichoic acid (LTA)
The teichoic acids that are anchored into the plasma membrane -
Omp C and F
Porins that allow hydrophillic solubles to cross the membrane -
2.5 The plasma membrane
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Plasma membrane (function)
Selective permeability barrier -
Fluid mosaic model
The arrangement of proteins and lipids to form a membrane -
Ion driven transport system (IDT)
Used for accumulation of manyions and amino acids -
Binding-protein dependent transport system (BPDT)
Used for sugars and amino-acids
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