Antibiotics and antibiotic resistance - Bacterial mechanisms of antibiotic resistance - Acquired resistance
3 important questions on Antibiotics and antibiotic resistance - Bacterial mechanisms of antibiotic resistance - Acquired resistance
7 Types of acquired resistance mechanisms
1. Ribosomal modification
2. DNA/RNA modification
3. Metabolic resistance
4. Prevent entry (small pores or outer membrane)
5. Enzymatically inactivate antibiotic
6. Efflux of the antibiotic
7. Modify target site
2. DNA/RNA modification
3. Metabolic resistance
4. Prevent entry (small pores or outer membrane)
5. Enzymatically inactivate antibiotic
6. Efflux of the antibiotic
7. Modify target site
Three mechanisms to acquire Sulfonamide resistance are:
1. Increased PABA can outcompete sulfonamide
2, Folate synthase altered to precent sulfonamide binding
3. Use alternative pathway to make folic acid
2, Folate synthase altered to precent sulfonamide binding
3. Use alternative pathway to make folic acid
Three ways to prevent antibiotic binding to ribosome
1. Methylation of ribosom so that atb cannot bind
2. Prevent aminoglycoside disruption of ribosomes by making it impossible for the drug to fit in the rRNA pocket
3. Ribosomal peptidyl transferase center (PT) modifiefd to inhibit atb binding
2. Prevent aminoglycoside disruption of ribosomes by making it impossible for the drug to fit in the rRNA pocket
3. Ribosomal peptidyl transferase center (PT) modifiefd to inhibit atb binding
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