Bacterial Toxins - Bacterial endotoxin - LPS and virulence of G- bacteria

3 important questions on Bacterial Toxins - Bacterial endotoxin - LPS and virulence of G- bacteria

5 Ways in which O poly may be involved in virulence

1. Adherence
2. Resistance to phagocytes; rough more engulfed
3. Carriers for toxic lipid A
4. Keeping atb's away from the membrane by binding them at the ends of the O poly relatively far away
5. Antigenic variation

Another important characteristic of o poly

Smoothness --> resistance to phagocytes

Injection of lipid A may cause (6)

1. Fever
2. Shock
3. Death
4. Change in white blood cell counts
5. Intravascular coagulation

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