Antibiotics and antibiotic resistance

9 important questions on Antibiotics and antibiotic resistance

What 3 groups of antimicrobial agents are used in the treatment of infectious diseases?

1. Antibiotics
2. Chemotherapeutic agents
3. Semisynthetic antibiotic

Who are the backbone of the antibiotics industry?

Actinomycetes

Bacillus species produce...

- Polypeptide antibiotics (Polymyxin)
- B polymyxa and B subtilis
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What is the most important property of an antimicrobial agent?

Selective toxicity; highly affective in inhibiting or killing the pathogen but no damage to host.

What two effects can antibiotics have?

1. Cidal (killing) effect
2. Static (inhibition) effect

Two categories of resistance

1. Inherent (natural)
2. Acquired

Three ways of inherent resistance

1. Target of antibiotic simply not present
2. Lack of a transport system to get it into the cell
3. Begin life with resistance

4 societal, medical and agricultural practices leading to atb resistance

1. Antibiotics in food and water that get there from cattle, fish, pigs etc
2. Non-therapeutic use in livestock to promote growth and prevent infections rather than to cure infections
3. Genetically modified crops; used to detect genes, can be taken up by microbes
4. Inappriopriate use in medical environment (where they are of no value)

8 Ways to combat antibiotic resistance

1. Search for new atb's
2. Stop the growth-promoting use in animals
3. Use the right one in an infection.
4. No unnecessary prescriptions
5. Finish prescriptions (use guidelines)
6. Combinations if necessary
7. Try other combinations if the first is not working
8. First cause dispersal; some may not work on biofilms

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