Bacterial Toxins - Bacterial protein toxins

4 important questions on Bacterial Toxins - Bacterial protein toxins

Toxins resemble enzymes in most ways (3)

1. Denatured by heat, acid and proteolytic enzymes
2. Act catalytically
3. Specifity of action

Of what two components do protein toxins consist?

1. Subunit A, responsible for enzymatic activity
2. Subunit B, responsible for binding

A-B or A-5B

Both subunits are synthesized separately, but associated by non-covalent bonds during secretion and binding to their target
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Two mechanisms of toxin-entry:

1. Direct entry
2.  Receptor-mediated endocytosis (RME)

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