Bacterial Colonization and Invasion - Colonization

7 important questions on Bacterial Colonization and Invasion - Colonization

Adhesin / Bacterial adhesion factor

Adhesion requires a receptor and a ligand; Adhesin is the bacterial ligand.

3 Evidence for specificity of adherence

1. Tissue tropism;
2. Species specifity
3. Genetic specificity

Genetic specifity within a species

Certain strains or races within a species genetically imune to a pathogen
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Adherence mechanisms  to cell or tissue specifity

1. Non-specific adherence: reversible attachment
2.  Specific adherence: irreversible permanent attachment
3. Non-specific adherence

3 experiments that prove the specific adherence

1. Binding isolated receptors or analogs
2. Isolated adhesins bind to eukaryotic cell-surface
3. Adhesion is inhibited by:

Pseudomonas, Vibrio and Neisseria possess:

Type 4 pilli that contain a protein subunit with a methylated amino acid, often phenylalanine.

Streptococcus pyogenes possesses

Produces multiple adhesins; M-protein, F-protein

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