Bacterial Toxins - Pore-forming toxins
3 important questions on Bacterial Toxins - Pore-forming toxins
Alpha toxin (alpha hemolysin)
Produced by S. Aureus and is the most potent membrane damager of this bacterium.
- Mushroom-shaped heptamer formed by seven toxin promoters
- Platelets and monocytes especially sensitive
- Mushroom-shaped heptamer formed by seven toxin promoters
- Platelets and monocytes especially sensitive
What cells are rich in sphingomyelinase?
Erythrocytes, leukocytes and macrophages
Lysteriolysin O (LLO)
- Listeria monocytogenes produces these
- non-enzymatic, cytolytic, cholesterol-dependent and pore-forming.
- Activated in the acidic environment of phagosomes.
- Ingested bacterium can lyse the phagosome and escape to the cytosol where it can grow.
- non-enzymatic, cytolytic, cholesterol-dependent and pore-forming.
- Activated in the acidic environment of phagosomes.
- Ingested bacterium can lyse the phagosome and escape to the cytosol where it can grow.
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