PHarmacogenetics of drug-induced birth defects: what is known so far

5 important questions on PHarmacogenetics of drug-induced birth defects: what is known so far

What kind of birth defects can become prevented with folate supplements?

NTD, but also oral cleft, cardiovascular defects, and urinary tract defects.

In what kind of malformations is oxidative stress involved?

- bone malformations
- limb defects
- NTDs
- oral clefts
- cardiovascular defects

Why can ACEinhibitors be teratogenic?

Because AT2 receptors are in high concentrations present in the fetus. Those concentrations decrease after birth. Therefore those drugs can give an increased risk of cardiovascular diseases and CNS malformations after preterm exposure.
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Why can COX-1 inhibitors be teratogenic?

This can be because cox-1 is also available in the fetus.

In what way can SSRI's cause several malformations?

In mice they seem to induce severe malformations but not in humans. This might be due to a difference in dosage.

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