Drug transporters in the human blood-placental barrier
4 important questions on Drug transporters in the human blood-placental barrier
How does the human placenta look like?
during pregnancy the syncytiotrophoblast contains still a few cytotrophoblasts and beyond this there is a cappilary endothelium, before fetal blood starts. Both syncytiotrophoblast and fetal cappilary endothelium express transporters. Also the basal and apical membranes express different transporters.
What kind of transporters are expressed in the human placenta?
- Pgp
- MRP1-3
- OATP8
- OATPA-E
- OAT4
- OCT3
- OCTN1
- OCTN2
- SERT (5-HT transporter)
- NET (noradrenaline transporter)
What are the organic cation transporters?
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What are the SERT and NET transporters?
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