Systematic reviews methodology and appraisal
13 important questions on Systematic reviews methodology and appraisal
What are some advantages of systematic reviews?
Comprehensive search of all potentially relevant studies
Use explicit, reproducible and uniformly applied criteria to select articles
Appraise the risk of bias for each study
Systematicallysynthesise the results of the studies
What are reasons for performing literature reviews?
too reduce bias
Reliable basis for decision making
explore variability
inform and influence research
What types of literature reviews are there?
Qualitative
Mixed methods
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What are the nine steps to conducting a systematic review?
2. Create plan
3. Search literature for potentially eligible studies
4. Apply eligible criteria to select studies
5. Assess the risk of bias of selected studies
6. Extract data from the selected studies
7. synthesise the data
8. interpret and report results
9. update the review
When do you have possible publication bias?
What is important when assessing the found studies for the criteria?
What is a big pro about combining samples of several studies?
Increases the power of the analysis
Improves the precision of the estimate of the effect
What are the standardised mean differences?
Difference in mean outcome between groups/SD of outcome among participants
What is a fixed effect? what is random effect?
Random effect: Studies are similar enough, but there are multiple true effects and these are pooled into a single estimated treatment effect
What are four possible effects of systematic review?
Inconclusive evidence
Insufficient evidence
No evidence of an effect, evidence of no effect
What are advantages of systematic reviews?
Hasten the assimilation of research into clinical practice
Assist in clarifying the heterogeneity of conflicting results between studies
Generalisability of the overall finding
guide decision making
What are disadvantages of systematic reviews?
Low quality primary data
Influence of retrospective knowledge on search criteria
What are two appraisal tools for systematic reviews?
Amstar - systematic reviews
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