Lung - Obstructive lung (airway) diseases

6 important questions on Lung - Obstructive lung (airway) diseases

What are the two types of Emphysema that cause significant airway obstruction and what is the difference between the two?

  1. centriacinar = emphysema in respiratory bronchiole
  2. panacinar = emphysema in aveolar duct

What are histologic features of Pulmonary emphysema?

destruction of alveolar walls (septa) without fibrosis, leading to enlarged air spaces

Chronic bronchitis is diagnosed on clinical grounds, what are these?

it is defined by the presence of a persistent productive cough for at least 3 consecutive months in at least 2 consecutive years.
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What are the histologic features of Chronic bronchitis?

enlargement of mucus-secreting glands, goblet cell metaplasia, and bronchiolar wall fibrosis.

What factors contribute to the development of asthma?

  • genetic predisposition to type I hypersensitivity (atopy)
  • acute and chronic airway inflammation
  • bronchial hyperresponsiveness to a variety of stimuli

What is characteristic of asthma?

reversible bronchoconstriction caused by airway hyperresponsiveness to a variety of stimuli.

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