Cell injury, Cell Death and Adaptations - Sequence of events in cell injury and cell death
9 important questions on Cell injury, Cell Death and Adaptations - Sequence of events in cell injury and cell death
Which pathway has a receptor-ligand interaction?
How is the Intrinsic pathway activated?
Effector molecules Bax, Bak increase mitochondrial permeability, but how does this result in apoptosis?
certain cofactors, activates caspase-9. The net result is the activation of a caspase cascade, ultimately leading to nuclear fragmentation and formation of apoptotic bodies.
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Hoe werkt de mitochondrial (intrinsieke) pathway bij apoptose?
- Er is cel schade dmv terugtrekken van GF's, DNA schade of verkeerd vouwen van eiwitten
- De BH3 sensor pikt dit op wat invloed heeft op de Bcl-2 family effectors
- Dit signaal wordt via de mitochondriën doorgegeven aan cytochroom c en andere pro-apoptotische eiwitten
- De Bcl-2 family effectors en cytochroom etc inhiberen de regulators als Bcl-2 en Bcl-x
- Hierdoor volgt caspase activatie wat zorgt voor apoptose
Hoe werkt de death receptor (extrinsieke) pathway bij apoptose?
- Er is receptor-ligand interactie van Fas en de TNF receptor
- Hierdoor komen adaptor proteïnen vrij
- Hierdoor volgt caspase activatie en celdood
Which proteins maintain mitochondrial permeability
In the caspase casacade, caspase-3 and caspase-6 are activated. What is their function?
In what ways does Necrose differs from Apoptose
- Necrose is pro-inflammatory, Induces repair and defence, Cell contents are released extracellularly.
- Is also occurs only in Pathologic situations and occurs now and then, whereas apoptose is part of normal physiology and occurs continuously
What is Autophagy and why does it occur?
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