Lung - Lung tumors

5 important questions on Lung - Lung tumors

What are the four major histologic types of carcinomas of the lung?

  1. adenocarcinoma
  2. squamous cell carcinoma
  3. small cell carcinoma (a subtype of neuroendocrine carcinoma)
  4. large cell carcinoma

Adenocarcinoma has a variety of growth patterns. Which are these?

  1. acinar (gland-forming)
  2. papillary; mucinous
  3. Micropapillary
  4. solid types (with mucin)

What is characteristic of Squamous cell carcinomas?

  • closely correlated with a smoking history
  • arise centrally in major bronchi
  • more common in men
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What are characteristics of Small cell lung carcinomas (SCLCs)

• >98% rokers
• More aggressive than NSCLC - Mean survival without treatment: 2-4 months
• Treatment: Chemotherapy
• 5 year survival: 2%

Besides chemo and surgery, what might also be an effective therapy for adenocarcinomas?

Targeted therapies, such as EGFR inhibitor therapy for adenocarcinomas with EGFR mutations

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