Female genital system and breast - Uterus - Proliferative lesions of the endometrium and myometrium

5 important questions on Female genital system and breast - Uterus - Proliferative lesions of the endometrium and myometrium

An important precursor of endometrial carcinoma is endometrial proliferation (hyperplasia). What can induce this?

An excess of estrogen relative to progestin, if sufficiently prolonged or marked, can induce exaggerated endometrial proliferation (hyperplasia)

Endometrial hyperplasia without cellular atypia carries a low risk for progression to endometrial carcinoma. What is characteristic for this?

“disordered” endometrium containing dilated glands.

What is the most cancer occurring in the female genital tract?

endometrial carcinoma
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What are the 2 types of endometrial carcinoma

  • Endometrioid carcinoma
    • associated with estrogen excess and endometrial hyperplasia.
    • inactivation of DNA mismatch repair genes and the PTEN gene.
  • Serous carcinoma
    • Mutations in the TP53
    • Worse prognosis

Leiomyomas are the most common benign tumor in females. Where does these arise?

Benign tumors that arise from the smooth muscle cells in the myometrium

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