Hemadynamic disorders, thromboembolism and shock - Hemostasis and thrombosis
13 important questions on Hemadynamic disorders, thromboembolism and shock - Hemostasis and thrombosis
Wat zijn de Weibel Palade bodies?
In de Weibel Palade bodies zijn deze stoffen opgeslagen.
How is hemostasis achieved?
- Vasoconstriction. This reduces blood flow
- Primary hemostasis: the formation of the platelet plug
- von Willebrand factor (vWF) and collagen promote platelet adherence and activation.
- Platelets bind via glycoprotein Ib (GpIb) receptors to von Willebrand factor (VWF) on exposed ECM
- secretion of platelet granule contents
- aggregation of the platelets
- Secondary hemostasis: deposition of fibrin.
- Tissue factor binds and activates factor VII
- GpIIb/IIIa receptors on activated platelets form bridging crosslinks with fibrinogen, leading to platelet aggregation
- cascade of reactions that results in Thrombin generation
- Trombin polymerizes fibrinogen into fibrin
- Clot stabilization and resorption
Does defects in vWF result in a disorder?
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Wat triggert de extrinsic pathway van coagulatie?
Leidt tot activatie VIIa. Calcium zorgt can voor activatie factor x.
How does asprin influences platelets aggregation?
What is the coagulation cascade?
a series of amplifying enzymatic reactions that lead to the deposition of an insoluble fibrin clot
What determines whether clot formation, propagation, or dissolution occurs?
balance between the anticoagulant and procoagulant activities of endothelium
normal endothelium releases a number of factors that inhibit platelet activation and aggregation. Name these
prostacyclin (PGI2), nitric oxide (NO), and adenosine diphosphatase
Name the primary abnormalities that lead to intravascular thrombosis (Virchow triad)
- endothelial injury
- stasis or turbulent blood flow
- hypercoagulability of the blood
How can endothelial injury lead to thrombosis?
What causes arterial and cardiac thrombosis and what is a contributing factor?
endothelial injury or dysfunction, as well as by forming countercurrents and local pockets of stasis
Turbulence (chaotic blood flow) is a contributing factor
Name High Risk for Thrombosis
Prolonged bed rest or immobilization
Myocardial infarction
Atrial fibrillation
Tissue injury (surgery, fracture, burn)
Cancer
What is mural thrombi?
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