Hematopoietic and lymphoid systems - Neoplastic lymphoid disorders
4 important questions on Hematopoietic and lymphoid systems - Neoplastic lymphoid disorders
Welke onderverdeling kun je maken als het gaat om T-cell lymphoma?
- Peripheral lymphomas = mature cellen. Die zitten in de lymph node.
Wat zijn de verschillen tussen hodgkin lymphoma en non-hodgkin lymphoma?
- Weinig subtypen + onder de microscoop hetzelfde.
- Typische distributie: lymfe nodes in de nek en gaat dan naar mediafragma (het gaat stapsgewijs)
- Tot waar het gedistribueerd is bepaald ook de uitkomst van de ziekte.
- Er zijn specifieke behandelplannen mede omdat de ziekte zich zo stapsgewijs verspreid.
- Heel veel verschillende soorten en verschillende entiteiten
- De distributie is heel onvoorspelbaar + afhankelijk van type lymfoma
- Je kunt het verloop niet voorspellen.
- Veel verschillende behandeling afhankelijk van de verschillende subtypen.
Wat is follicular lymphoma?
- Het komt van B-lymphocyten (germinal center B-cell) die in de lymph node zitten
- Meestal niet agressief = indolent.
- Komt vaak voor >50 jaar.
- Het is een non-hodgkin lymphoma
Microscopisch beeld: het groeit in follicles.
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Wat is Burkitt lymphoma?
- Non-hodgkin
- Mature B-cell (germinal centre)
- Agressief
- Extranodal presentation (abdomen of mandibula/maxilla)
- Vaak bij kinderen en jong volwassenen
- Vaak in Africa
- Veroorzaakt door een translocatie = Myc => hoge proliferatie van de B-lymphocyten.
Microscopisch:
Sterrenhemel: witte stippen = macrofagen die eten de cellen die prolifereren.
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