Hematopoietic and lymphoid systems - White cell disorders - Neoplastic proliferations of white cells
12 important questions on Hematopoietic and lymphoid systems - White cell disorders - Neoplastic proliferations of white cells
What is the difference between leukemias and lymphomas
Acute Leukemia is a fast progressive disease with lots of proliferation. What are the symptoms of bone marrow failure and organ infiltration?
◦ Bleeding
◦ Anemia (fatigue, dyspneu)
◦ Hepatosplenomegaly
◦ CNS dysfunction, headache
From which cells can Acute Lymfoblastic Leukaemia (ALL) originate from?
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In what age group does ALL occur the most and is considered a favorable prognostic marker?
What is characteristic for AML?
Associated with mutations that lead to expression of abnormal transcription factors, which interfere with myeloid differentiation
WHat is characteristic for CLL?
• Indolent course (=causing little or no pain), commonly associated with immune abnormalities, including increased susceptibility to infection and autoimmune disorders
The 2 main groups of acute lymphoma are ALL and AML. Why is this distinction been made?
There are 2 types of Chronic leukemias. Which are these?
- CML (= myeloproliferative disease)
- CLL (= NHL)
What are characteristics for CML?
- Myeloproliferative disease t(9;22)
- Stamcel disease
- Bone marrow with myelopoiesis and often megakaryocytes, normal maturation
- In PB leukocytosis with mature and immature myeloid cells
- Huge splenomegaly
- In chronic phase few complaints
- Progression to AML (blasts crisis)
What is characteristic for follicular lymphomas
What is characteristic for Burkitt lymphoma
Aggressive mature B tumor. Often latently infected by EBV
What are the most common lymphomas in adults?
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