Disease of the immune system - Autoimmune diseases
7 important questions on Disease of the immune system - Autoimmune diseases
What is the principal mechanism of central tolerance?
Name the mechanism of Peripheral Tolerance
- Anergy. Functional inactivation (rather than death) of lymphocytes
- Suppression by regulatory T cells (Treg)
- Deletion by apoptosis.
Name genetic factor that contributes to the Pathogenesis of autoimmune diseases
- Disease-associated MHC alleles
- Fas, FasL, AIRE, CTLA-4
- Other susceptibility-loci: some genes are known, some are still only speculative
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Name infectious factors that (can) contribute to pathogenesis of auto-immune diseases
- Activation of co-stimulators
- Molecular mimicry
- Tissue destruction: release of selfantigens normally hidden.
- Tissue damage → ‘epitope spreading’
Wat is de pathogenesis achter SLE?
What factors lead to a failure of self-tolerance and the development of autoimmunity?
- inheritance of susceptibility genes that disrupt different tolerance pathways
- infections and tissue injury that exposes self-antigens and activates APCs and lymphocytes in the tissues.
Wat is de pathogenese achter systemic sclerosis?
-> meer TGF-beta -> meer collageen en eiwitten in ECM -> fibrose in skin en andere organen
Antigen is waarschijnlijk centromeer proteins.
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