Neoplasia - Hallmarks of cancer
8 important questions on Neoplasia - Hallmarks of cancer
RAS is the most commonly mutated oncogene in human tumors? How does this muntation leads to a tumor?
What is the function of the Rb protein? And how can this tumor supressor gene cause cancer?
To regulate the G1/S checkpoint.
If pRb is inactivated, there is no checkpoint control and causes uncontrolled cell division and accumulation of DNA damages
Name an oncogenic virus that alters the function of Rb
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In normal situations, what is te functon of p53
- Senescence
- DNA repair
- induction of cell death (apoptosis/autophagy)
Name a common mechanism of inactivation of tumor suppressor gene, which does not occur is p53
What is the function of telomerase?
What is Angiogenesis in tumors
How can tumor cell avoid immune destruction?
However, if the tumor can avoid immune destruction, it can cause the expression of another peptide/ligand on APC or CTL. This causes that the CTL doesn't recognise the tumor peptide and doesn't induce killing of the tumor (cells)
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