Development of the urinary system

12 important questions on Development of the urinary system

What are the functions of the kidneys?

  • Metabolic balance
  • clearance of water and water products
  • erytropoetin
  • renin-angiotensin system
    • regulates blood pressure

What is the functional unit of the kidney and what does it consist of?

The nephron, consisting of the glomerulus (filtering blood) and the tubular system

What does CAKUT stand for?

Congenital anomalies of the kidney and urinary tract
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What mechanism does prevents reflux (urine going back up) and how does it work?

The flap-valve mechanism: urine compresses the ureter between the bladder mucosa and the bladder wall muscle, thus creating a flap-valve mechanism that prevents reflux.

During development, the ureter is going through the vladder wall into the bladder; once this bladder muscle contracts, it constricts the ureter, preventing urine from going back up. When the ureter doesn't penetrate sufficiently, ureter can possibly flow up.

Why are men more likely to develop bladder problems?

Because posterior urethral valves can develop, constricting the urethra and increasing the pressure in the bladder.

What is the prenatal function of the kidney?

Diuresis starts at the 12th week of gestation, and is essential for amniotic fluid. However, waste clearance is not that important because there is dialysis via the placenta.

  • How can CAKUT be detected?

Antenatal screening (ultrasound screening) at 12 and 20 weeks, but not af 32 weeks (prenatal screening), causing.a lot of congenital disorder to be overseen. For example, urine build-up, seen as black spots.

What is prenatal hydronephrosis?

Here, there is a dilated collecting system with too much water. Dilatation does not, however, equal obstruction. Prenatal dilatation somewhat predicts postnatal dilatation.

What is potter sequence?

Potter facies with flattened nose, low ears and thickened fingers, is characteristic of a foutus who has been exposed to oligohydramnios, or reduced amount of amniotic fluid. This causes squeezing of the foetus by the pressure caused by lack of fluid. Potter sequence is lethal because there is no amniotic fluid, which is vital for lung development, causing lung hypoplasia. Here, lung and kidney development overlap.

What is multicystic dysplastic kidney?

Here, the interaction between the ureteric bud and the mesenchyme is aberrated, causing the formation of dysfunctional cysts.

What is congenital solitary functioning kidney?

  • Unilateral renal agenesis
  • unilateral multicystic dysplastic kidney

What is hypoplastic kidney?

  • Smaller kidney, therefore less nephrons --> higher amount of blood pressure
  • Barker hypothesis - preferential treatment of organs during problems in pregnancy (e.g low birth weight)

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