Cancer epidemiology
3 important questions on Cancer epidemiology
To grade the evidence convincing, one should?
Strong and unlikely to change in the future
No unexplained heterogeneity
At least 2 independent cohort studies
Good quality studies that account for error
Dose-response
Robust evidence from laboratory studies
No unexplained heterogeneity
At least 2 independent cohort studies
Good quality studies that account for error
Dose-response
Robust evidence from laboratory studies
To grade the evidence probable, one should?
No unexplained heterogeneity
At least 2 independent cohort or 5 case-control studies
Good quality studies that account for error
Dose-response
Plausible evidence from laboratory studies
At least 2 independent cohort or 5 case-control studies
Good quality studies that account for error
Dose-response
Plausible evidence from laboratory studies
What are the main problems with randomized Randomized controlled trials?
Ethical
Lack of compliance
Short duration
Intermediate endpoints
Timing of exposure
Costly
Lack of compliance
Short duration
Intermediate endpoints
Timing of exposure
Costly
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