Tumor blood vessels and angiogenesis
11 important questions on Tumor blood vessels and angiogenesis
What are the causes of VEGF expression?
What is the angiogenesis dogma?
What happens when normoxia is occuring?
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What happens when hypoxia is occuring?
What is a genetic disease linked to hypoxia + explain the disease
What is the difference between tip and stalk cells (both endothelial cells)?
In which ways can the VEGF pathway be targeted (in order to counter angiogensis)?
- VEGF inhibitors : prevention of binding to receptor and thereby inhibiting the whole VEGF signaling pathway
- Small molecules: binding to the intracellular phosphorylation site and prevents ATP binding to the VEGFR receptor, blocking intracellular signaling.
- Anti-DDL4: no blood vessel formation since no stalk cells are recruited
- physiological inhibitors: counteract the action of VEGF and controls VEGF activity.
What are advantages of anti-angiogenic therapies compared to conventional treatment?
- The endothelium is well accessible to intravenous drugs
- No resistance is expected (because endothelium is genetically stable)
What can the angiogenic factor VEGF cause?
- Endothelial cell proliferation
- expression of proteases for the degradation of the basement membrane.
- the production of tissue factors which creates fibrin
What happens if VEGF is expressed?
What is a glioblastoma?
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