Hematopoetic stem cells
11 important questions on Hematopoetic stem cells
Which two forms of leukemia are there?
What are the characteristics of hematological malignancies
- Uncontrolled growth of blood cells
- often immature non-functional cells which invade the whole circulation (within the bone marrow, within lymph nodes & spleen, within the blood)
- They suppress the development of normal blood cells, leading to anemia, more bleedings and persistent infections.
- Treatment of these hematological malignancies is dependent on disease risk and health status of a patient (less harsh therapy is used for people with co-morbidities/people of old age)
What is a treatment option for leukemia patients?
- Higher grades + faster learning
- Never study anything twice
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What is the main difference between leukemia and (solid) tumors?
From which 3 sources can stem cells obtained?
What are the pros and cons of obtaining stem cells from bone marrow?
Cons: slow reconstitution, higher relapse chance, painful for donor
How are peripheral blood stem cells isolated from donors?
What are the pros and cons of obtaining stem cells from peripheral blood?
cons: possibly higher GVHD, possibly higher relapse chance
How are stem cells from cord blood collected?
What are the pros and cons of isolating stem cells from cord blood?
cons: often not enough cells, because small volume
How and why is the processing of allogeneic apheresis products done?
- spin down apheresis cells, remove plasma
- immunophenotyping of CD34+ cells and cell count
- possible manipulation (selecting CD34+ cells / depleting T cells)
The question on the page originate from the summary of the following study material:
- A unique study and practice tool
- Never study anything twice again
- Get the grades you hope for
- 100% sure, 100% understanding
