Paper: Regeneration of the entire human epidermis using transgenic stem cells
9 important questions on Paper: Regeneration of the entire human epidermis using transgenic stem cells
What are the four degrees of burn wounds?
- Sunburn
- Blistering
- Epidermal defects, going into the dermis --> hair follicles are lost
- complete loss of skin
What is the golden standard in therapy for therapy of burn wounds?
What are the pros and cons of autologous split skin mesh grafts?
Cons: you create even more wounds, sometimes there is not enough healthy skin (for example when the whole body is burned).
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Explain the principle of cultured epithelial autografts
What are the two types of heritable skin diseases?
What are the three types of epidermolysis bullosa?
- EB simplex: autosomal dominant (mutation in keratin 5/14)
- Junctional EB: autosomal dominant (mutations in Laminin, Collagen 17)
- Dystrophic EB: autosomal dominant or recessive (mutations in collagen 7)
To what manifestations can the three different types of EB lead?
Junctional EB: separation of the dermis & epidermis
Dystrophic EB: very deep dermal cleavage
What are the two treatment options for junctional EB?
- Gene addition --> by viral transduction
- Gene correction --> by Crispr-Cas9
Explain the principle of correction of junctional EB by using iPSCs
- Take mutant somatic cells from patient with heritable disease
- Make iPSCs
- Correct the gene defect in vitro (large cell population)
- generate keratinocytes or fibroblasts (full differentiation)
- transplant an epidermal sheet of corrected cells to the patient
The question on the page originate from the summary of the following study material:
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