Connections between nerve and muscle - Loss of multiple innervation
6 important questions on Connections between nerve and muscle - Loss of multiple innervation
Which two ions regulate the detachment of motorneuron axons on skeletal muscle cells?
How does contractile activity induced release of K+ and Ca2+ end up in a retracted axon?
- K+ is released into the extracellular space
- K+ stimulates K+ dependent Ca2+ channels on the pre-synaptic terminal membrane
- Ca2+ influx in the pre-synaps stimulates Ca2+ dependent proteases
- Attack of neurofilaments by proteases
- Axon retraction
How can adult motorneurons innervate muscles if they are constantly attacked by Ca2+?
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What happens with the axons that have retracted from primary muscle fibers?
What does a denervated muscle fiber do to survive?
Is contractile activity beneficial for muscle innervation?
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