Stress and aging
5 important questions on Stress and aging
What happens to your body when aging?
- osteoporosis
- slow neural brain recovery
- worsening diabetes type 2
- fatigue, muscle dystrophy
primarily effects of cortisol, excessive cortisol levels: the cause of dying in many species
What is negative feedback inhibition?
What happens to the cortisol and negative feedback inhibition during aging?
• Older organisms: feedback dysregulated and /or set-point too high: too much cortisol
• Role hippocampus (cortisol-feedback location)
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What happens to the set point of cortisol during stress?
- older organisms: set point is higher -->
role hippocampus as cortisol feedback center.
What is the glucocorticoid neurotoxicity hypothesis?
Stress --> excessive cortisol secretion --> hippocampus loses neurones
--> hippocampus is failing in the negative feedback inhibition
excessive cortisol secretion --> ever more cortisol/ -related damage in body --> premature death.
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