Substance Misuse

5 important questions on Substance Misuse

Substitute prescribing for Heroin

This is prescribing of drugs in a controlled manner to reduce use of illicit drugs.

Methadone is the liquid
This is a full agonist with a longer half-life. Therefore, the withdrawal will be longer but milder.
While try to detox over months, sometimes long-term is needed for maintenance.

Buprenorphine is the sublingual tablet.
It is a partial agonist and blocks the euphoric effects of heroin.

Effects of Ecstasy (MDMA)

Increase serotonin release and reuptake inhibition
Cross between stimulant and hallucinogen.
Use is confined to weekends.

Sense of empathy and closeness to others
Chatty
Dance relentlessly
Bruxism
Nausea
Vomiting
Sweating
Can die from hyperthermia and dehydration

Local complications of IV Drug Use

Abscess
Cellulitis
DVT (valves are damaged)
Emboli
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Systemic complications of IV Drug Use

Septicaemia
Infective endocarditis
Blood-borne infections
Increased risk of overdose

Effects of mixing Benzos and Alcohol

Magnify depressive effects
Less control over movements
Depression of the autonomic nervous system so leads to respiratory depression.

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