Molecular and Biological Aspects of Apoptosis - Immunity and apoptosis
3 important questions on Molecular and Biological Aspects of Apoptosis - Immunity and apoptosis
Role of apoptosis in the adaptive immune system
Function of central tolerance
Function in peripheral deletion events
Function in the effector immune response
- Deletion of self-reactive B/low-affinity B cells in lymphoid tissue
- Deletion of self-reactive T cells in the thymus
Function in peripheral deletion events
- Inactivation of self-reactive peripheral T cells that evaded negative selection
- Limitation of the expansion of T cell clones after elimination of antigens
- Immune privilege in tissues
Function in the effector immune response
- Killing mechanism of virus-infected or transformed cells by CTCs
Function of Bim and Fas in regulation of lymphocyte numbers
- If antigen is cleared rapidly, T cells will accumulate Bim and the cells die in a Bim-dependent manner
- If antigens persist, T cells might receive successive activation, resulting in increased survival factors and expression of FasL. This engages Fas on T cells and dendritic cells, resulting in cell death.
Induction of autoimmune reactions
Long exposure to cell death which is not properly cleared.
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