Cellular composition and timescales
6 important questions on Cellular composition and timescales
What new perspective of the cell is offered by systems biology?
On average, proteins are 1 protein-diameter separated in distance in the cytosol; the proteinprotein distance is therefore about 10 nm. What is a consequence of this macromolecular crowding?
In which 2 processes can metabolism roughly be divided?
- catabolism converts nutrients into building blocks and energy,
- anabolism converts the products of catabolism into cellular macromolecules: DNA, RNA, lipids (membranes) and protein.
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How do molecules move trough the cell?
Which 3 factors determine the rate of a spontaneous complex formation reaction?
- The concentrations of A and B
- The likelihood that they find each other by chanche
- their tendency to form a complex once they have collided ("stickyness")
* all three are captured in a single rate constant ka. (Dissociation --> kd)
Why does diffusion limit life?
molecules cannot move faster than by diffusion.
The speed of reactions involving two (or more) substrates is therefore limited by diffusion rates
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