Constructing neuronal circuits

5 important questions on Constructing neuronal circuits

What are 4 requirements for the formatting of a neuronal network

  • Establish polarization
  • neurite outgrowth
  • synaptic contact
  • stabilization of the contact

What happens when there is an attractive cue

More exocytosis --> filopodia can extend --> actin assembly and cell adhesion

What happens when there is a repulsive cue

More endocytosis --> remove part of membrane and insert it somewhere else --> actin disassembly and adhesion
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What happens when there is inside-out signaling from the integrins

There is more cell adhesion due to a more stretched form

Name the 5 steps of synapse formation

  1. Outgrowth makes contact with axon due to cadherins
  2. insertion of the active zone
  3. pre and post align --> neurexin and neurligin
  4. EphB activation --> post synaptic receptor insertion
  5. synapse maturation

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