Molecular signaling within neurons

4 important questions on Molecular signaling within neurons

How is a GTP-ase turned of

By GAP, it removes a phosphate from ATP resulting in ADP

Name the cascade for when norepinephrine binds to its receptor

Receptor si beta-adrengric --> G-protein--> adenylyl cyclase --> cAMP --> protein kinase A

Name the cascade for when glutamate binds to its receptor

Receptor is mGLuR --> g-protein --> phospholipase C --> splits in DAG and IP3 --> DAG activtes PKC and IP3 actives the release of Ca2+
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How is the calcium gradient maintained?

  • ATP-ase calcium pump
  • calcium buffers like calmodulin
  • Na=/Ca2+ exchnage
  • ER and Mitochondria are used as storage

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