Common themes in neurodegenerative diseases

6 important questions on Common themes in neurodegenerative diseases

What happens to proteins which cannot be refolded?

Get tagged by ubiquitin and degredated

What forms of degredation are there>

Ubiquitin proteasome system(UPS)->for defective/misfolded proteins
Autophagy-> organelles, aggregates and long lived proteins

How do inclusion bodies originate?

If ubiquitine degradation fails they aggregate to oligomers into fibrils into inclusion bodies
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What does the UPR do in response to prions?

Chronically reduces protein synthesis via perk

Why cant perk be used in therapeutic target against prions?

Reduced translation results in loss of critical proteins and thus in neurodegeneration

What are other ways to influence the pathways of the upr?

Isrib and sephin1

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