Genetics of schizophrenia

7 important questions on Genetics of schizophrenia

Who have schizophrenia more, men or women?

Men in ratio of abut 7:5

Who were the genain quadruplets?

4 sisters with schizophrenia all with schizophrenia but differen symptoms

What people were used in adoption studies?

high risk adoptees
And risk of disease in relatives of schizophrenic adoptees compared to controls
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What are the two hypotheses regarding schizophrenia genetics?

Common disease common variant
Common disease rare variant

What was one of the first candidate genes?

DISC1

Why is DISC1 not so convincing?

Translocation was found in only one family
Association is a-specific
No functional variants

What was the outcome of twin and adoption studies?

High concordance rate and similarity between DZ twin and siblings suggests a prenatal/postnatal environmental effect

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