Postnatal brain development

8 important questions on Postnatal brain development

What is the chemo-affinity hypothesis?

Molecular coding defines synapse specficity. So DSCAMS are matching guidance cues.

Why is the chemo-affinity hypothesis not true?

The stochastic expression results in self avoidance of sister axons
Segregated dendritic fields
Patterned innervation of photoreceptor axons

So it is more likely that DSCAMS are repulsive guidance cues.

How is first contact mediated between synapses?

Adhesion molecules such as nectins and cadherins, which form temporary connections between pre and postsynaptic partners
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How come a synapse becomes active?

A signal goes to the postsynaptic cell where, neuregulin allows the expression of more receptors. Thus allowing more connectivity strengthening the connection.

Which three factors show changes in synapse maturation?

Spine shape, size and number

What happens in the case of a lazy eye?

One of the eyes is deprived of input, therefore there is no equal development of synapses in the visual cortex

What is the limiting factor in ocular dominance plasticity?

The extracellular matrix

How can ocular dominance be restored?

By degrading the extracellular matrix by chondroitinase

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