Lithium toxicity

5 important questions on Lithium toxicity

  1. Which level of Lithium serum is toxic

* levels >1,5 mmol/L

Clinical effects of lithium toxicity  ( 1,5)?

GI- gastro intestinal  (increasing anorexia, nausea and diarrhea
CNS effects: muscle weakness, drowsiness, confusion, ataxia , tremor en muscle twitching

Wat happend when serum Lithium is  above 2 mol/L?

Increased disorientation
seizures --> can progress in coma, ultimately death
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When plasma level more than 3 mmol/L?

Peritoneal or haemodialysis is often used

What is the most risk factor for Lithium toxicity?

*Changes in sodium levels ( natrium)
* the way the body handles sodium ( for example: low salt diets, dehydration,
*drug interactions,
* Addison's disease;

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