Immunohistochemical localization of BiP/GRP78 and p-PERK in neurons in the temporal cortex and hippocampus

6 important questions on Immunohistochemical localization of BiP/GRP78 and p-PERK in neurons in the temporal cortex and hippocampus

Did the Glia cells show expression of BiP?

Very low signals in all investigated areas.

In which cell type was the expression of BiP most prominent?

In neurons (of both AD and non-AD)

In which brain region was the difference in expression of BiP most pronounced?

In the hippocampus
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Was there any activity of p-PERK found in non-demented controls?

No, not in both regions

Was there any relationship found between BiP expression and NFT formation?

not really, which may suggest BiP expression comes prior to tangle formation.

What is an intriguing finding regarding BiP expression and tangle occurence?

More BiP staining seems to be correlated to less tangle occurence.

The question on the page originate from the summary of the following study material:

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