Summary: Thema 2.1

Read the summary and the most important questions on Thema 2.1

• 1 Week 1

• 1.1 Most important things week 1

• How to recognize a MPE?

  Maculopapula erythema is recognized by >90% of the body that is erythemous with muculas and papules all over the body. You can recognize it due to itch, it starts proximally.

• How to recognize DRESS?

  Drug reaction with eosinophil and systemic symptoms is a worse-case scenario than MPE. It is a type 4b reaction. It includes facial edema and lymphadenopathy.

• How to recognize AGEP?

  : acute generalyzed exanthemotous pustulosis. Neutrophil reaction type 4d, that involved pustules all over the body. A lot of neutrophils and the pustules are sterile.

• How to recognize stephens johnsen syndrom/TEN

  Mucosal ulcers, blisters and painful skin.

• 2 Week 2

• 2.1 Lecture introduction joint probelems

  This is a preview. There are 3 more flashcards available for chapter 2.1
  Show more cards here

• Name the typical presentation of arthritis.

  Common signs of arthritis include:
  

  • Joint pain and tenderness
  • Swelling and inflammation
  • Stiffness, particularly in the morning or after periods of inactivity
  • Reduced range of motion
  • Warmth or redness over affected joints
  • Fatigue and general malaise, night sweats. 
  • CRP and ESR are elevated and there is anemia due to less EPO production. 

  
  Symptoms can vary depending on the type of arthritis.

• Which joint distribution from left to right fits specific diseases and why.

  Left; symmetric, wrist, smaller hand and feet joints. Lumbar and thoracic vertebras not involved, while the C1 and C2 are. 
  
  Middle : asymmetric; one wrist and ankle. Could be psoriatic arthritis. 
  
  Right: Ankylosing spondylitis. Lumbar and thoracic involvement.

• Name some typical features in Rheumatoid arthritis and what are some extra-articular manifestations.

  Involvement of the PIP, MCP, and MTP joints. The wrist could be involved as well; often it is symmetrical. The cervical vertebra's on level 1 and 2 could be involved. The morning stiffness > 1 hour. 50% have RF and anti-CCP. The general age of onset is between 40-60 years old. More common amongst woman.
  
  Extra-articular manifestations are nodules (subcutaneous or in the lungs) ; vasculitis (vessel wall inflammation), serositis (pleuritis, pericarditis). Pathogenesis due to IL6 and TNFalpha. Polyarthritis.

• Name some typical features in psoriatic arthritis.

  Asymmetric, involvement of the wrist or ankle. Nail lesions, scaling, stretch side of the elbow and knees.

• Name some typical features in ankylosing arthritis

  Age of onset is around 20-30. Often involvement of the spine (lumbar or thoracic).

• How can you differentiate between osteoarthritis and rheumatoid arthritis.

  Morning stiffness is osteoarthritis is less than 30 minutes in osteoarthritis.