Summary: Toxicologie | Rientjes
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3 Mechanisms ofToxicity
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mode of action induction of cancer
covalent binding to DNA -
4 Absorbtion, distribution and excretion
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Dynamic phase/toxicodynamics
reaction with the toxicological receptor. Toxic effect is generated. What the drug does to the body
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5 Biotransformation
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wat zijn belagrijkste reacties van PhaseI?
oxidatie, reductie, hydrolise -
6 Toxicokinetics
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one- compartment model
plasma levels and tissue levels are modeled to be similar. -
1st odrder kinetics
kinetic model :rate of elimination of a compound is proportional to the amount in het body -
which parameters are used as input in PBPK-models?
blood flow rates, tissue volumes, kinetic parameters for bio-transformation -
7 Chemical carcinogenesis
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from tissues of ectodermal & endodermal(epithelial).
Carcinoma. Gastric adenocarcinoma -
how is the cancer initiated by asbestos?
asbestof fibers become surrrounded by glycprotein an cannot be adequately removed by macrophages -
What is the purpose of a carcinogenicity study with laboratory animals?
To determine cancer risks for humans
•To establish a dose-response relationship -
short term testing
predicting carcinogenity
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