Absorption, distribution and excretion of chemicals

4 important questions on Absorption, distribution and excretion of chemicals

How does the ionisation of chemicals and blood flow affects xenobiotic absorption?

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1. Recall commonalities and differences of the intestinal, lung, skin, blood brain barrier and placental barrier.

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What are the consequences of the entero-hepatic
cycle? What is it?

Swallowed drug-> digestive system –> hepatic portal system-> liver –> rest of body
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Where are the places of storage for toxicants in the body?

In tissue= fat, liver and bone
1. In fat, especially highly lipophilic compounds
a. Exposure upon fasting and breast feeding
2. Bone
a. Skeletal uptake from extracellular fluid to the hydroxyapatite crystals of bone mineral

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