Toxicokinetics - Absorption and Distribution + Toxicokinetics - Metabolism and Excretion (TOX 3)
9 important questions on Toxicokinetics - Absorption and Distribution + Toxicokinetics - Metabolism and Excretion (TOX 3)
What can happen to a compound after oral intake?
- Enterohepatic circulation
- Presystemic elimination
- Portal vein
What is presystemic elimination?
What does the absorption of gasses in the lungs depend on?
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What is the formula for absorption?
With f is the absorption efficiency
What happens with lipophilic compounds, like PCB?
Where do Pb2+, Sr2+, and F- accumulate?
Where does cadmium accumulate?
What are the three phases of biotransformation?
- Hydrolysis/reduction/oxidation to create a reactive “handle” to the compound (-OH), (=O); (-COOH)
- Conjugation, coupling of a water soluble molecule to the handle of the compound
- Elimination/excretion: removal of the conjugated product from the body
What are enzyme properties needed for biotransformation?
- Specificity
- Saturation
- Inhibition
- Induction
The question on the page originate from the summary of the following study material:
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