Processes of gene expression and protein turnover
20 important questions on Processes of gene expression and protein turnover
What is the 3rd end in the DNA?
Which parts of the pre-mRNA, introns and exons, are coding for proteins?
Which protection mechanisms are attached to mRNA to protect it from direct degradation?
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Where are the genes for rRNA located?
Why do humans not express myosin 2b, while we have the gene?
How do you get a transcription factor to the nucleus?
- express specific factor (MyoD)
- change conformation of present transcription factor by phosphorylation (PGC-1a)
What is the role of generic exercise in translation?
How does exercise affect the RNA in cells?
Why can hypertrophy sometimes not work in older people?
- lack of amino acids
- DNA mutation
- epigenetic modifications
- low eIF factors
What are the four complexes involved in protein degradation?
- calpains
- lysosomes
- ubiquitine proteasome
- oxidative stress
What activates calpains?
What is the main function of calpain?
initiate apoptosis
What are the mayor cytoskeletal proteins?
- titin
- desmin
- nebulin
How is calpain directed apoptosis regulated?
- adaptor proteins (TNF-a)
- mitochondrial dysfunction
What is the main triggering factor for cytoskeletal structure degradation?
What is the difference between caspase and calpain?
In what kind of environment do lysosomal enzymes work best?
Why is it important to keep the energy status of the cel high enough just after training?
What is the function of the protein desmin?
What is the function of the protein nebuline?
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