Tumorbio-10

5 important questions on Tumorbio-10

How does miRNA develop in cancer?

miRNA gene -> pri-miRNA -> pre-miRNA -> dicing -> unwinding miRNA duplex;
1) global loss of miRNA -> loss of TS miRNAs -> accumulation of oncogenes
2)accumulation of oncogenic miRNA -> translation inhibition -> miRNA cleavage or LO genes

What is the function of HMGA?

architectural elements that affect chromatin

What is the function of the let-7 binding sites?

repression of HMGA2
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What is the effect of the deletion of let-7 in HMGA2?

deregulation of HMGA2 expression -> oncogenic transformation -> CRC

What is the function of miRNA-15a-16-1?

miRNA decrease anti-apoptotic BCL2

The question on the page originate from the summary of the following study material:

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