Tumorbio-6
4 important questions on Tumorbio-6
What is the effect of PML-RARalfa?
How do you treat PML/RARalfa?
2) dissociation of co-repressor complex
3) Displacement of HDACs creates a hyperacetylated chromatin state
4) normal differntiation possible
What is the effect of CBF?
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What is the effect of a mutation or translocation in CBF?
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