Tumorbio-6

4 important questions on Tumorbio-6

What is the effect of PML-RARalfa?

constitutive repression RARalfa regulated genes

How do you treat PML/RARalfa?

1) degradation of oncofusion PML-RAR
2) dissociation of co-repressor complex
3) Displacement of HDACs creates a hyperacetylated chromatin state
4) normal differntiation possible

What is the effect of CBF?

increases the affinity to dna, protects RUNX against proteolytic cleavage
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What is the effect of a mutation or translocation in CBF?

no differentiation

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