Tumorbio-9
6 important questions on Tumorbio-9
What are the p53 target genes?
What is the direct function of tp53?
- cdc25c = cell cycle arrest
- cMYC = inhibit cell proliferation
- Survivin = apoptosis
- VEGFA = inhibition angiogenises
How does tp53 get degraded and saved?
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What is the function of p19arf?
What are the consequences of the inactivation of the p53 pathway in tumrs?
2) DNA viruses: hPV
3) MDM2 accumulation (sarcomas, glioblastomas)
4) inactivation of CDKN2A/p19
5) destabilization; mutation in miRNA
What is the difference between MEN2A/B?
B = MTC early and mucosal neuromas on lips or tongue
The question on the page originate from the summary of the following study material:
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