Tumorbio-9

6 important questions on Tumorbio-9

What are the p53 target genes?

Bcl-2 & IGF-1R

What is the direct function of tp53?

direct repression of transcription through repression of:
- cdc25c = cell cycle arrest
- cMYC = inhibit cell proliferation
- Survivin = apoptosis
- VEGFA = inhibition angiogenises

How does tp53 get degraded and saved?

normaly rapidely degraded by E3 liagse MDM2/HDM2 but when there is genotoxic- and cellular stress which degradtes MDM2
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What is the function of p19arf?

temporarily eliminates MDM2 -> drags it is to the nucleus

What are the consequences of the inactivation of the p53 pathway in tumrs?

1) remaining transcractivation activity
2) DNA viruses: hPV
3) MDM2 accumulation (sarcomas, glioblastomas)
4) inactivation of CDKN2A/p19
5) destabilization; mutation in miRNA

What is the difference between MEN2A/B?

A = medullary thyroid cancer
B = MTC early and mucosal neuromas on lips or tongue

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