And : Identifying Genes
37 important questions on And : Identifying Genes
Definition quantitative trait locus
What is allelic association?
What is continuous phenotype?
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Definition candidate gene approach
What is single nucleotide polymorphism (SNP)?
Which mutation is more damaging?
What is wrong with repeated sequences?
What are synonymous SNPs?
Definition copy number variants (CNVs)
What is a polygenic score?
What is a methode to detect SNPs and microsatellite markers?
What are the DNA markers and why?
The two major strategies for identifying genes for human behavior
- Allelic association
- Linkage
Definition linkage (behavior traits)
What is the (dis)advantage of linkage?
What is the (dis)advantage of association?
Definition affected sib-pair linkage design
What is the weakness of allelic associtation?
What are haplotype blocks?
What is genetic anticipation?
What is the HapMap project?
What is whole-genome amplification?
Methods to test a continuous phenotype
Why should we do association studies?
- Learn about the disease biology
- Predict disease based on the genome
- Use genetics to improve epidemiology
What is genetic effect?
What is a genome-wide association study (GWAS)?
What is premutation and fragile X syndrome?
What is whole-genome sequencing?
What is Polymerase chain reaction (PCR)?
What is a primer?
What is a polymerase?
What is a haploid genotype (haplotype)?
What is linkage analysis?
What are single-gene disorders?
What is a candidate gene?
What is the linkage disequilibrium?
What are the broad aims of contemporary genetics?3
2. Interpret > the (biological) effects these SNPs have on a trait
3. Predict > for individuals or groups, their risk for disease
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